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Second-Generation Aspirin and Indomethacin Prodrugs Possessing an O 2 -(Acetoxymethyl)-1-(2-carboxypyrrolidin-1-yl)diazenium-1,2-diolate Nitric Oxide Donor Moiety: Design, Synthesis, Biological Evaluation, and Nitric Oxide Release Studies

✍ Scribed by Velázquez, Carlos A.; Chen, Qiao-Hong; Citro, Michael L.; Keefer, Larry K.; Knaus, Edward E.


Book ID
126876286
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
173 KB
Volume
51
Category
Article
ISSN
0022-2623

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Celecoxib prodrugs possessing a diazen-1
✍ Khaled R.A. Abdellatif; Morshed A. Chowdhury; Carlos A. Velázquez; Zhangjian Hua 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 284 KB

A new class of anti-inflammatory (AI) cupferron prodrugs was synthesized wherein a diazen-1-ium-1,2diolato ammonium salt, and its O 2 -methyl and O 2 -acetoxyethyl derivatives, nitric oxide (NO) donor moieties were attached directly to an aryl carbon on a celecoxib template. The percentage of NO rel