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A diazen-1-ium-1,2-diolate analog of 7-azabenzobicyclo[2.2.1]heptane: Synthesis, nitric oxide and nitroxyl release, in vitro hemodynamic, and anti-hypertensive studies

✍ Scribed by Bhardwaj, Atul; Huang, Zhangjian; Kaur, Jatinder; Yang, Fenghua; Seubert, John M.; Knaus, Edward E.


Book ID
122849446
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
663 KB
Volume
23
Category
Article
ISSN
0960-894X

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Celecoxib prodrugs possessing a diazen-1
✍ Khaled R.A. Abdellatif; Morshed A. Chowdhury; Carlos A. VelΓ‘zquez; Zhangjian Hua πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 English βš– 284 KB

A new class of anti-inflammatory (AI) cupferron prodrugs was synthesized wherein a diazen-1-ium-1,2diolato ammonium salt, and its O 2 -methyl and O 2 -acetoxyethyl derivatives, nitric oxide (NO) donor moieties were attached directly to an aryl carbon on a celecoxib template. The percentage of NO rel