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Characterization and nitric oxide release studies of lipophilic 1-substituted diazen-1-ium-1,2-diolates

✍ Scribed by Dominick C Roselle; Daniel J Smith


Book ID
114163369
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
181 KB
Volume
51
Category
Article
ISSN
0168-3659

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Celecoxib prodrugs possessing a diazen-1
✍ Khaled R.A. Abdellatif; Morshed A. Chowdhury; Carlos A. VelΓ‘zquez; Zhangjian Hua πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 English βš– 284 KB

A new class of anti-inflammatory (AI) cupferron prodrugs was synthesized wherein a diazen-1-ium-1,2diolato ammonium salt, and its O 2 -methyl and O 2 -acetoxyethyl derivatives, nitric oxide (NO) donor moieties were attached directly to an aryl carbon on a celecoxib template. The percentage of NO rel