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Novel non-peptidic neuropeptide Y Y2 receptor antagonists

✍ Scribed by Jill A. Jablonowski; Wenying Chai; Xiaobing Li; Dale A. Rudolph; William V. Murray; Mark A. Youngman; Scott L. Dax; Diane Nepomuceno; Pascal Bonaventure; Timothy W. Lovenberg; Nicholas I. Carruthers


Book ID
108073198
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
178 KB
Volume
14
Category
Article
ISSN
0960-894X

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The identification and subsequent optimisation of a selective non-peptidic NPY Y2 antagonist series is described. This led to the development of amine 2, a selective, soluble NPY Y2 receptor antagonist with enhanced CNS exposure.