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Novel N-Substituted 3α-[Bis(4‘-fluorophenyl)methoxy]tropane Analogues: Selective Ligands for the Dopamine Transporter

✍ Scribed by Agoston, Gregory E.; Wu, Jae H.; Izenwasser, Sari; George, Clifford; Katz, Jonathan; Kline, Richard H.; Newman, Amy Hauck


Book ID
127232384
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
274 KB
Volume
40
Category
Article
ISSN
0022-2623

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A Novel Photoaffinity Label for the Dopamine Transporter Based on N-Substituted 3α-[Bis(4'-fluorophenyl)methoxy]tropane. -The azide (V) together with the radio-labeled analogue are synthesized by similar procedures. Preliminary results show that (V) binds irreversibly to the dopamine receptor. The