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Highly Selective Chiral N-Substituted 3α-[Bis(4‘-fluorophenyl)methoxy]tropane Analogues for the Dopamine Transporter: Synthesis and Comparative Molecular Field Analysis

✍ Scribed by Robarge, Michael J.; Agoston, Gregory E.; Izenwasser, Sari; Kopajtic, Theresa; George, Clifford; Katz, Jonathan L.; Newman, Amy Hauck


Book ID
125444227
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
313 KB
Volume
43
Category
Article
ISSN
0022-2623

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A Novel Photoaffinity Label for the Dopamine Transporter Based on N-Substituted 3α-[Bis(4'-fluorophenyl)methoxy]tropane. -The azide (V) together with the radio-labeled analogue are synthesized by similar procedures. Preliminary results show that (V) binds irreversibly to the dopamine receptor. The