ChemInform Abstract: A Novel Photoaffinity Label for the Dopamine Transporter Based on N-Substituted 3α-[Bis(4′-fluorophenyl)methoxy]tropane.

✍ Scribed by G. E. AGOSTON; R. VAUGHAN; J. R. LEVER; S. IZENWASSER; P. D. TERRY; A. H. NEWMAN

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 33 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199811165

✦ Synopsis

A Novel Photoaffinity Label for the Dopamine Transporter Based on N-Substituted 3α-[Bis(4'-fluorophenyl)methoxy]tropane.

-The azide (V) together with the radio-labeled analogue are synthesized by similar procedures. Preliminary results show that (V) binds irreversibly to the dopamine receptor. The label binds covalently. -(AGOSTON, G. E.;