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ChemInform Abstract: Enantioselective Synthesis of S-(+)-2β-Carboalkoxy-3α-[bis(4-fluorophenyl)methoxy]tropanes as Novel Probes for the Dopamine Transporter.

✍ Scribed by Mu-Fa Zou; Gregory E. Agoston; Yuri Belov; Theresa Kopajtic; Jonathan L. Katz; Amy Hauck Newman


Publisher
John Wiley and Sons
Year
2010
Weight
37 KB
Volume
33
Category
Article
ISSN
0931-7597

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A Novel Photoaffinity Label for the Dopamine Transporter Based on N-Substituted 3α-[Bis(4'-fluorophenyl)methoxy]tropane. -The azide (V) together with the radio-labeled analogue are synthesized by similar procedures. Preliminary results show that (V) binds irreversibly to the dopamine receptor. The