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ChemInform Abstract: Synthesis and Ligand Binding of Nortropane Derivatives: N-Substituted 2β-Carbomethoxy-3β-(4′-iodophenyl)nortropane and N-(3- Iodoprop-(2E)-enyl)-2β-carbomethoxy-3β-(3′,4′-disubstituted phenyl)nortropane. New High-Affinity and Selective Compounds for the Dopamine Transporter.

✍ Scribed by P. EMOND; L. GARREAU; S. CHALON; M. BOAZI; M. CAILLET; J. BRICARD; Y. FRANGIN; L. MAUCLAIRE; J.-C. BESNARD; D. GUILLOTEAU

Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
28
Category
Article
ISSN
0931-7597

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SUMMARY In order to study the dopamine transporter by \(\mathrm{PET}\), we prepared ( \(E\) )-N-(3-bromoprop-2-enyl)\(2 \beta\)-carbomethoxy-3 \(\beta\)-(4'-tolyl) nortropane (PE2Br) and its radiobrominated analogue. PE2Br and \(\left[{ }^{76} \mathrm{Br}\right] \mathrm{PE} 2 \mathrm{Br}\) were synt