S-Benzylisothiourea derivatives as small
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Kenji Matsuno; Kazushige Takai; Yoshinobu Isaka; Yuka Unno; Masayuki Sato; Osamu
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Article
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2010
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Elsevier Science
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English
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S-Benzylisothiourea 3a was discovered by its ability to inhibit indoleamine-2,3-dioxygenase (IDO) in our screening program. Subsequent optimization of the initial hit 3a lead to the identification of sub-lM inhibitors 3r and 10h, both of which suppressed kynurenine production in A431 cells. Synthesi