๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Novel candesartan derivatives as indoleamine 2,3-dioxygenase inhibitors

โœ Scribed by Matsuno, Kenji; Yamazaki, Hiroshi; Isaka, Yoshinobu; Takai, Kazushige; Unno, Yuka; Ogo, Naohisa; Ishikawa, Yoshinobu; Fujii, Satoshi; Takikawa, Osamu; Asai, Akira


Book ID
126800105
Publisher
The Royal Society of Chemistry
Year
2012
Tongue
English
Weight
491 KB
Volume
3
Category
Article
ISSN
2040-2503

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


S-Benzylisothiourea derivatives as small
โœ Kenji Matsuno; Kazushige Takai; Yoshinobu Isaka; Yuka Unno; Masayuki Sato; Osamu ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 416 KB

S-Benzylisothiourea 3a was discovered by its ability to inhibit indoleamine-2,3-dioxygenase (IDO) in our screening program. Subsequent optimization of the initial hit 3a lead to the identification of sub-lM inhibitors 3r and 10h, both of which suppressed kynurenine production in A431 cells. Synthesi