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Synthesis and biological evaluation of novel tryptoline derivatives as indoleamine 2,3-dioxygenase (IDO) inhibitors

โœ Scribed by Tanaka, Minoru; Li, Xin; Hikawa, Hidemasa; Suzuki, Takafumi; Tsutsumi, Katsuhiko; Sato, Masashi; Takikawa, Osamu; Suzuki, Hideharu; Yokoyama, Yuusaku

Book ID
118280634
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
733 KB
Volume
21
Category
Article
ISSN
0968-0896

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Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in the process of cancer angiogenesis. A series of quinoline amide derivatives were prepared and found to be good inhibitors of VEGFR-2. The inhibitory activities were investigated against VEGFR-2 kinase and human umbilical