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Design, synthesis and biological evaluation of pyridine acyl sulfonamide derivatives as novel COX-2 inhibitors

โœ Scribed by Xiang Lu; Hui Zhang; Xi Li; Guo Chen; Qing-Shan Li; Yin Luo; Ban-Feng Ruan; Xian-Wei Chen; Hai-Liang Zhu

Book ID
113495487
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
356 KB
Volume
19
Category
Article
ISSN
0968-0896

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Design, synthesis and biological evaluat
Design, synthesis and biological evaluation of quinoline amide derivatives as novel VEGFR-2 inhibitors
โœ Ying Yang; Lei Shi; Yang Zhou; Huan-Qiu Li; Zhen-Wei Zhu; Hai-Liang Zhu ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 321 KB

Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in the process of cancer angiogenesis. A series of quinoline amide derivatives were prepared and found to be good inhibitors of VEGFR-2. The inhibitory activities were investigated against VEGFR-2 kinase and human umbilical