𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Novel Benzofuran Derivatives for PET Imaging of β-Amyloid Plaques in Alzheimer's Disease Brains

✍ Scribed by Ono, Masahiro; Kawashima, Hidekazu; Nonaka, Akemi; Kawai, Tomoki; Haratake, Mamoru; Mori, Hiroshi; Kung, Mei-Ping; Kung, Hank F.; Saji, Hideo; Nakayama, Morio

Book ID
127123654
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
249 KB
Volume
49
Category
Article
ISSN
0022-2623

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

A novel 18F-labeled pyridyl benzofuran d
A novel 18F-labeled pyridyl benzofuran derivative for imaging of β-amyloid plaques in Alzheimer’s brains
✍ Yan Cheng; Masahiro Ono; Hiroyuki Kimura; Shinya Kagawa; Ryuichi Nishii; Hideo S 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 456 KB

A potential probe for PET targeting b-amyloid plaques in Alzheimer's disease (AD) brain, FPYBF-1 (5-(5-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N,N-dimethylpyridin-2-amine), was synthesized and evaluated. In experiments in vitro, FPYBF-1 displayed high affinity for Ab(1-42) aggregates (K

Diphenylpropynone derivatives as probes
Diphenylpropynone derivatives as probes for imaging β-amyloid plaques in Alzheimer’s brains
✍ Masahiro Ono; Hiroyuki Watanabe; Rumi Watanabe; Mamoru Haratake; Morio Nakayama; 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 428 KB

A new series of diphenylpropynone (DPP) derivatives for use in vivo to image β-amyloid (Aβ) plaques in the brain of patients with Alzheimer's disease (AD) were synthesized and characterized. Binding experiments in vitro revealed high affinity for Aβ (1-42) aggregates at a K(i) value ranging from 6 t