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Push–pull benzothiazole derivatives as probes for detecting β-amyloid plaques in Alzheimer’s brains

✍ Scribed by Masahiro Ono; Shun Hayashi; Hiroyuki Kimura; Hidekazu Kawashima; Morio Nakayama; Hideo Saji

Book ID
118426575
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
651 KB
Volume
17
Category
Article
ISSN
0968-0896

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A new series of diphenylpropynone (DPP) derivatives for use in vivo to image β-amyloid (Aβ) plaques in the brain of patients with Alzheimer's disease (AD) were synthesized and characterized. Binding experiments in vitro revealed high affinity for Aβ (1-42) aggregates at a K(i) value ranging from 6 t