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Synthesis and evaluation of benzothiophene derivatives as ligands for imaging β-amyloid plaques in Alzheimer's disease

✍ Scribed by Young Soo Chang; Jae Min Jeong; Yun-Sang Lee; Hyung Woo Kim; Rai B. Ganesha; Young Ju Kim; Dong Soo Lee; June-Key Chung; Myung Chul Lee


Book ID
116799019
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
331 KB
Volume
33
Category
Article
ISSN
0969-8051

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A new series of diphenylpropynone (DPP) derivatives for use in vivo to image β-amyloid (Aβ) plaques in the brain of patients with Alzheimer's disease (AD) were synthesized and characterized. Binding experiments in vitro revealed high affinity for Aβ (1-42) aggregates at a K(i) value ranging from 6 t