A potential probe for PET targeting b-amyloid plaques in Alzheimer's disease (AD) brain, FPYBF-1 (5-(5-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N,N-dimethylpyridin-2-amine), was synthesized and evaluated. In experiments in vitro, FPYBF-1 displayed high affinity for Ab(1-42) aggregates (K
✦ LIBER ✦
18F-Labeled benzylideneaniline derivatives as new ligands for β-amyloid plaque imaging in Alzheimer's disease
✍ Scribed by Hak Jeong Lee; Jae Min Jeong; Ganesha Rai; Yun-Sang Lee; Young Soo Chang; Young Ju Kim; Hyung Woo Kim; Dong Soo Lee; Jung Key Chung; Inhee Mook-Jung; Myung Chul Lee
- Book ID
- 116799283
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 586 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0969-8051
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