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Synthesis and Evaluation of 18 F-Labeled 2-Phenylbenzothiazoles as Positron Emission Tomography Imaging Agents for Amyloid Plaques in Alzheimer’s Disease

✍ Scribed by Serdons, Kim; Terwinghe, Christelle; Vermaelen, Peter; Van Laere, Koen; Kung, Hank; Mortelmans, Luc; Bormans, Guy; Verbruggen, Alfons


Book ID
124071607
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
362 KB
Volume
52
Category
Article
ISSN
0022-2623

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Synthesis and evaluation of two fluorine
✍ K. Serdons; D. Vanderghinste; M. Van Eeckhoudt; P. Borghgraef; H. Kung; F. Van L 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 368 KB

## Abstract Uncharged derivatives of thioflavin‐T have known __in vitro__ and __in vivo__ affinity for amyloid β. We synthesized and evaluated two derivatives with a fluorine‐18 labelled fluoropropoxy substituent either at the 6‐position or at the 2′‐position of the 2‐(4′‐aminophenyl)‐1,3‐benzothia