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Synthesis and biological evaluation of (E)-3-styrylpyridine derivatives as amyloid imaging agents for Alzheimer's disease

✍ Scribed by Masahiro Ono; Mamoru Haratake; Morio Nakayama; Yoshikazu Kaneko; Koichi Kawabata; Hiroshi Mori; Mei-Ping Kung; Hank F. Kung


Book ID
116798853
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
577 KB
Volume
32
Category
Article
ISSN
0969-8051

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A series of chaclone derivatives containing an indole moiety were evaluated in competitive binding assays with AΞ²(1-42) aggregates versus [(125)I]IMPY. The affinity of these compounds ranged from 4.46 to >1008 nM, depending on the substitution on the phenyl ring. Fluorescent staining in vitro showed