Novel Arylpyrazino[2,3 -c ][1,2,6]thiadiazine 2,2-Dioxides as Inhibitors of Platelet Aggregation. 1. Synthesis and Pharmacological Evaluation
✍ Scribed by Campillo, Nuria; García, Concepción; Goya, Pilar; Páez, Juan A.; Carrasco, Emilio; Grau, Manuel
- Book ID
- 120489655
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 69 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0022-2623
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A mild synthesis of 6,7-dihydrothiazolo[3,2-b]-1,2,4-thiadiazine 1,1-dioxides involving a thiazolinic diazadiene and sulfonyl chlorides is reported. Full characterisation of these novel cyclic sulfonamides is described.
## Abstract The synthesis of novel analogues of foric acid (FA) antagonists derived from the pyrazino[2,3‐c]‐1,2,6‐thiadiazine 2,2‐dioxide system incorporating the glutamic acid side chain at the 7‐position is described. No significant DHFR inhibition of cytotoxic activity has been found with these