✦ LIBER ✦

Notes. Synthesis of C 14 Labelled Dimethylformamide and 3-(2-Amino-butyl-1-C 14 )indole Acetic Acid Salt

✍ Scribed by Szmuszkovicz, Jacob; Thomas, R

Book ID: 126216601
Publisher: American Chemical Society
Year: 1961
Tongue: English
Weight: 367 KB
Volume: 26
Category: Article
ISSN: 0022-3263
DOI: 10.1021/jo01062a616

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Synthesis of 14C-labeled halogen substit

Synthesis of 14C-labeled halogen substituted indole-3-acetic acids

✍ Bruce G. Baldi; Janet Pernise Slovin; Jerry D. Cohen 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 French ⚖ 254 KB 👁 1 views

## Abstract A general method for microscale synthesis of ^14^C‐labeled indole‐3‐acetic acids with halogen substitutions in the benzene ring is described. The method utilizes halogen substituted phenylhydrazines reacted with [^14^C]‐2‐oxoglutarate to generate the halogenated indole‐3‐acetic acid. 3‐

Synthesis of 3-indolyl(1-14C)acetic, 3-i

Synthesis of 3-indolyl(1-14C)acetic, 3-indolyl(2-14C) acetic and 3-indolyl(1,2-14C2)acetic acids

✍ K. V. Viswanathan; T. V. Ramaamurthy 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 French ⚖ 208 KB 👁 1 views

## Abstract The synthesis of 3‐indolylacetic acid labelled with ^14^C in side chain carbon atoms has been effected using (1‐^14^C)glycolic acid, (1,2‐^14^C~2~)glycolic acid and (2‐^14^C)glycolic acid in an yield of 40‐60%. Some of the parameters that affect the synthesis have been studied and the r

Labelling of an anti-inflammatory agent

Labelling of an anti-inflammatory agent with carbon-14, synthesis of 5-methoxy-2-methyl-1-(3,4-methylenedioxybenzoyl) indole-2-14C-3-acetic acid

✍ Iwao Nakatsuka; Masaaki Hazue; Yoshiaki Makari; Kazuo Kawahara; Michio Endo; Aki 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 266 KB 👁 1 views

## Abstract 5‐Methoxy‐2‐methyl‐1‐(3,4‐methylenedioxybenzoyl)indole‐3‐acetic acid (ID‐955)(I), a new anti‐inflammatory agent, was labelled with carbon‐14 at C‐2 position of indole nucleus for the use of metabolic studies. The procedure used is shown in Fig. 1 and 2. Levulinic‐4‐^14^C acid was synthe

Synthesis of homovanillic acid-2−14C, ho

Synthesis of homovanillic acid-2−14C, homoprotocatechuic acid-2−14C, 3′, 4′-dihydroxymandelic acid-2−14C and 1-(4 hydroxy-3-methoxyphenyl)-ethylene glycol-1−14C

✍ A. A. Liebman; D. H. Malarek; A. M. Dorsky; H. H. Kaegi 📂 Article 📅 1971 🏛 John Wiley and Sons 🌐 French ⚖ 493 KB 👁 1 views

Specifically labelled phenylacetic acid and mandelic acid derivatives, metabolites of L-Dopa, have been synthesized via the intermediary labelled benzyl alcohols, which were prepared by reduction of the methyl esters of the appropriate benzoic acids. The benzyl alcohols have been converted to the co

Synthesis of 14C-labelled (R)-α-amino-6,

Synthesis of 14C-labelled (R)-α-amino-6,7-dimethyl-3-(phosphonomethyl)-2-quinolinepropanoic acid

✍ Britt-Marie Swahn; Fredrik Andersson; Benjamin Pelcman; Johan Söderberg; Alf Cla 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 258 KB 👁 1 views

Synthesis of 14C-labeled 3-{[1-ethoxycar

Synthesis of 14C-labeled 3-{[1-ethoxycarbonyl-3-phenyl-(1S)-phenyl-(1S)-propyl]amino}-2,3,4,5-tetrahydro-2-oxo-1H-1-(3S)-benzazepine-1-acetic acid hydrochloride ([14C]CGS 14824A)

✍ Naba K. Chaudhuri; Russell Patera; Bohdan Markus; Ming-Sang Sung 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 French ⚖ 334 KB

The title compound, CGS 148248, was synthesized with a '%-label in the azepine ring in 14 steps starting with l-bromo-3-phenylpropane (1> and K1%N in an overall yield of 1.31%. The reaction of I with K 1 k N yielded the nitrile 2 which upon hydrolysis followed by ring closure gave a-tetral~ne-l-~~c