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Normalisation of sister chromatid exchange frequencies in Bloom's syndrome by euploid cell hybridisation

✍ Scribed by BRYANT, EILEEN M.; HOEHN, HOLGER; MARTIN, GEORGE M.


Book ID
109714383
Publisher
Nature Publishing Group
Year
1979
Tongue
English
Weight
252 KB
Volume
279
Category
Article
ISSN
0028-0836

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Sister chromatid exchange and cell cycle
✍ S. Ved Brat πŸ“‚ Article πŸ“… 1979 πŸ› Springer 🌐 English βš– 656 KB

Sister chromatid exchange (SCE) has been studied in the fibroblasts of five Bloom's syndrome patients, one heterozygote, and two normal individuals. The high frequency of SCE already known in the lymphocytes of Bloom's syndrome was also found in the fibroblasts of all five patients. However, populat

Frequency of sister chromatid exchanges
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Cocultivation of fibroblast cells from a male patient with Bloom syndrome (BS) and a female control reduced the rate of sister chromatid exchanges in the BS cells from a mean of 54 SCE per metaphase (range 42--65) to 41 (range 24--59). Medium used to culture control cells for 48 h also reduced the r

Suppression of the frequencies of sister
✍ P. P. W. Buul; A. T. Natarajan; Elly A. M. Verdegaal-Immerzeel πŸ“‚ Article πŸ“… 1978 πŸ› Springer 🌐 English βš– 164 KB

The effect of co-cultivation of Bloom's syndrome fibroblasts with Chinese hamster ovary cells (CHO) on the incidence of sister chromatid exchanges (SCEs) was studied. The results show that suppression of the frequency of SCEs in Bloom's syndrome cells occurs only if cell to cell contact is present w