Sister chromatid exchange (SCE) has been studied in the fibroblasts of five Bloom's syndrome patients, one heterozygote, and two normal individuals. The high frequency of SCE already known in the lymphocytes of Bloom's syndrome was also found in the fibroblasts of all five patients. However, populat
Normalisation of sister chromatid exchange frequencies in Bloom's syndrome by euploid cell hybridisation
β Scribed by BRYANT, EILEEN M.; HOEHN, HOLGER; MARTIN, GEORGE M.
- Book ID
- 109714383
- Publisher
- Nature Publishing Group
- Year
- 1979
- Tongue
- English
- Weight
- 252 KB
- Volume
- 279
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/279795a0
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π SIMILAR VOLUMES
Cocultivation of fibroblast cells from a male patient with Bloom syndrome (BS) and a female control reduced the rate of sister chromatid exchanges in the BS cells from a mean of 54 SCE per metaphase (range 42--65) to 41 (range 24--59). Medium used to culture control cells for 48 h also reduced the r
The effect of co-cultivation of Bloom's syndrome fibroblasts with Chinese hamster ovary cells (CHO) on the incidence of sister chromatid exchanges (SCEs) was studied. The results show that suppression of the frequency of SCEs in Bloom's syndrome cells occurs only if cell to cell contact is present w