A comparison is made between the incidences of sister chromatid exchanges (SCE) per chromosome and group of chromosomes and breakage, visible at metaphase like open gaps, breaks, and breaks involved in chromatid interchange formation (CI) in Bloom's syndrome. It can be shown that the two levels of b
Sister-chromatid exchanges induced by ultraviolet light in Bloom's syndrome fibroblasts
β Scribed by T. Kurihara; K. Tatsumi; H. Takahashi; M. Inoue
- Book ID
- 116108208
- Publisher
- Elsevier Science
- Year
- 1987
- Weight
- 440 KB
- Volume
- 183
- Category
- Article
- ISSN
- 0167-8817
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Sister chromatid exchange (SCE) has been studied in the fibroblasts of five Bloom's syndrome patients, one heterozygote, and two normal individuals. The high frequency of SCE already known in the lymphocytes of Bloom's syndrome was also found in the fibroblasts of all five patients. However, populat
Cocultivation of fibroblast cells from a male patient with Bloom syndrome (BS) and a female control reduced the rate of sister chromatid exchanges in the BS cells from a mean of 54 SCE per metaphase (range 42--65) to 41 (range 24--59). Medium used to culture control cells for 48 h also reduced the r