Sister chromatid exchange (SCE) has been studied in the fibroblasts of five Bloom's syndrome patients, one heterozygote, and two normal individuals. The high frequency of SCE already known in the lymphocytes of Bloom's syndrome was also found in the fibroblasts of all five patients. However, populat
Sister chromatid exchange in cells metabolically coupled to Bloom's syndrome cells
โ Scribed by Schonberg, Steven; German, James
- Book ID
- 109717884
- Publisher
- Nature Publishing Group
- Year
- 1980
- Tongue
- English
- Weight
- 338 KB
- Volume
- 284
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/284072a0
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A comparison is made between the incidences of sister chromatid exchanges (SCE) per chromosome and group of chromosomes and breakage, visible at metaphase like open gaps, breaks, and breaks involved in chromatid interchange formation (CI) in Bloom's syndrome. It can be shown that the two levels of b
It is suggested that the somatic recombination observed in Bloom's syndrome and cells treated with mitomycin C may be the result of selection for recombination events that can occur only between homologous segments of DNA, rather than a result of somatic pairing in the nucleus.