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Suppression of the frequencies of sister chromatid exchanges in Bloom's syndrome fibroblasts by co-cultivation with Chinese hamster cells

✍ Scribed by P. P. W. Buul; A. T. Natarajan; Elly A. M. Verdegaal-Immerzeel

Publisher: Springer
Year: 1978
Tongue: English
Weight: 164 KB
Volume: 44
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00295412

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✦ Synopsis

The effect of co-cultivation of Bloom's syndrome fibroblasts with Chinese hamster ovary cells (CHO) on the incidence of sister chromatid exchanges (SCEs) was studied. The results show that suppression of the frequency of SCEs in Bloom's syndrome cells occurs only if cell to cell contact is present with CHO cells, without any effect on the SCE frequency in the latter. It is suggested that possible genetic heterogeneity between different Bloom's syndrome patients can be studied using the method of co-cultivation.

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