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Loss of high frequency of sister chromatid exchanges in Epstein-Barr virus-established lymphoblastoid cell lines from two patients with Bloom's syndrome

✍ Scribed by Tomoko Hashimoto; Shinobu Gamo; Jun-ichi Furuyama; Hide-aki Chiyo


Publisher
Springer
Year
1983
Tongue
English
Weight
216 KB
Volume
63
Category
Article
ISSN
0340-6717

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✦ Synopsis


Seven lymphoblastoid cell lines were established through transformation by Epstein-Barr virus of peripheral blood lymphocytes from two patients with Bloom's syndrome (BS), the parents of a patient, and normal controls. High baseline levels of sister chromatid exchanges (SCEs) in peripheral blood lymphocytes of BS were reduced to about 10% of their initial value in BS lymphoblastoid cell lines, and the elevation of SCE frequencies induced by ethylmethanesulfonate was the same as in controls.


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