✦ LIBER ✦

Loss of high frequency of sister chromatid exchanges in Epstein-Barr virus-established lymphoblastoid cell lines from two patients with Bloom's syndrome

✍ Scribed by Tomoko Hashimoto; Shinobu Gamo; Jun-ichi Furuyama; Hide-aki Chiyo

Publisher: Springer
Year: 1983
Tongue: English
Weight: 216 KB
Volume: 63
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00285403

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✦ Synopsis

Seven lymphoblastoid cell lines were established through transformation by Epstein-Barr virus of peripheral blood lymphocytes from two patients with Bloom's syndrome (BS), the parents of a patient, and normal controls. High baseline levels of sister chromatid exchanges (SCEs) in peripheral blood lymphocytes of BS were reduced to about 10% of their initial value in BS lymphoblastoid cell lines, and the elevation of SCE frequencies induced by ethylmethanesulfonate was the same as in controls.

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