## Abstract Pharmacokinetic and bioavailability parameters of propranolol were estimated in 10 healthy adult subjects after single oral doses of two commercial tablet formulations of propranolol hydrochloride (2 ร 40 mg). Plasma concentrations of propranolol were determined by a highโperformance li
Nonlinear pharmacokinetics of unbound propranolol after oral administration
โ Scribed by Robert J. Straka; Richard L. Lalonde; John A. Pieper; Michael B. Bottorff; David M. Mirvis
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 431 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0022-3549
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## Abstract Several research groups have reported that in man the oral administration of propranolol with food leads to a marked increase (about 50 per cent) in the area under the plasma concentrationโtime curve (AUC~po~) of this well absorbed and highly metabolized drug. An acute change in hepatic