The relative bioavailability of two 100-mg disopyramide formulations which showed almost an 8-to 10-fold difference in their dissolution rates at pH 1.2 and 6 -8 was determined in eight healthy subjects using a randomized block design. Although no significant differences in relative bioavailability
Comparative pharmacokinetics of unbound disopyramide enantiomers following oral administration of racemic disopyramide in humans
โ Scribed by Harumi Takahashi; Hiroyasu Ogata; Mikiko Shimizu; Kayoko Hashimoto; Keiso Masuhara; Kazuko Kashiwada; Kazuhiko Someya
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 329 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0022-3549
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