Pharmacokinetics of ketoprofen enantiomers in monkeys following single and multiple oral administration
โ Scribed by David Mauleon; Ricard Mis; Joan Ginesta; Elvira Ortega; Jaime Vilageliu; Nuria Basi; Germano Carganico
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 514 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0899-0042
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๐ SIMILAR VOLUMES
Ketoprofen (KT), a chiral nonsteroidal anti-inflammatory drug (NSAID), is marketed and used as a racemic mixture. In healthy volunteers, negligible differences have been reported between the plasma time courses of KT enantiomers. Using a stereospecific high-performance liquid chromatographic (HPLC)
Acebutolol (AC), is a chiral, i-adrenergic blocking agent which possesses partial agonist activity and is metabolized to an equipotent chiral metabolite, diacetolol (DC). The enantiomeric disposition of AC is reported following racemic administration as a single oral (p.o., 50 mg kg -1 ) or as a mul
The purpose of this study was to characterize CI-992 pharmacokinetics and pharmacokinetics/pharmacodynamics (PK/PD) in sodium deplete monkeys. Panels of monkeys were administered CI-992 as a 1 h intravenous infusions (0.1 and 1 mg kg -1 ) or as single oral doses (0, 10, 50, and 100 mg kg -1 ). Mean