Nonlinear stereoselective pharmacokinetics of ketoconazole in rat after administration of racemate
โ Scribed by Dalia A. Hamdy; Dion R. Brocks
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 327 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0899-0042
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract The pharmacokinetics of ornidazole (ONZ) were investigated following i.v. administration of racemic mixture and individual enantiomers in beagle dogs. Plasma concentrations of ONZ enantiomers were analyzed by chiral highโperformance liquid chromatography (HPLC) on a Chiralcel OBโH colum
Acebutolol (AC) is a chiral b-adrenergic blocking drug, possessing intrinsic sympathomimetic activity (ISA), and is useful clinically as the racemate in treating hypertension. Utilizing a stereospeciยฎc high-performance liquid chromatographic (HPLC) assay, the enantiomeric disposition of AC and its m
## Abstract The main objective of this study was to determine the pharmacokinetics of the enantiomers of desbutylhalofantrine (DHF), a metabolite of halofantrine (HF), in the rat. Rats received either intravenous (2 mg/kg) or oral (7 mg/kg) (ยฑ)โDHF HCl, or (ยฑ)โHF HCl intravenously (3 mg/kg). Enanti