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Non-steroidal anti-inflammatory drugs have potent anti-fibrillogenic and fibril-destabilizing effects for α-synuclein fibrils in vitro

✍ Scribed by Mie Hirohata; Kenjiro Ono; Akiyoshi Morinaga; Masahito Yamada

Book ID
116784934
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
960 KB
Volume
54
Category
Article
ISSN
0028-3908

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## Abstract The aggregation of alpha‐synuclein (αS) in the brain has been implicated as a critical step in the development of Lewy body diseases (LBD) and multiple system atrophy (MSA). Among the antioxidant strategies proposed, increasing evidence points to the possibility of achieving neuroprotec