No association between Parkinson's disease and monoamine oxidase A and B gene polymorphisms
β Scribed by Shinichiro Nanko; Akira Ueki; Mineko Hattori
- Book ID
- 116125342
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 247 KB
- Volume
- 204
- Category
- Article
- ISSN
- 0304-3940
No coin nor oath required. For personal study only.
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~ W e have tested the hypothesis that DNA markers in the MAOA gene show allelic association with bipolar affective disorder. Eighty-four unrelated Caucasian patients with DSM 111-R bipolar disorder and 84 Caucasian controls were typed for three markers in MAOA a dinucleotide repeat in intron 2, a VN
Monoamine oxidase B (MAO-B) is implicated in the cause of Parkinson's disease (PD) because of its role in metabolizing the neurotoxin l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine, and forming H,02 during dopamine metabolism. Altered MAO-B activity has been observed in PD platelets. Polymerase chain