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NMR studies of carbonic anhydrase-fluorinated benzenesulfonamide complexes

✍ Scribed by Dugad, L. B.; Cooley, C. R.; Gerig, J. T.


Book ID
126862947
Publisher
American Chemical Society
Year
1989
Tongue
English
Weight
730 KB
Volume
28
Category
Article
ISSN
0006-2960

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Fluorine and nitrogen-15 NMR experiments are described which show that 3,5-diΓ‘uorobenzenesulfonamide binds to human carbonic anhydrase I in a 1 : 1 complex, that the bound inhibitor is present as an anion and that the aromatic ring of the inhibitor undergoes rapid rotation in the complex in spite of