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Tritium NMR studies of the human carbonic anhydrase I–benzenesulfonamide complex

✍ Scribed by A.S. Culf; J.T. Gerig; P.G. Williams

Book ID
110369428
Publisher
Springer Netherlands
Year
1997
Tongue
English
Weight
122 KB
Volume
10
Category
Article
ISSN
0925-2738

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Fluorine and nitrogen-15 NMR experiments are described which show that 3,5-diÑuorobenzenesulfonamide binds to human carbonic anhydrase I in a 1 : 1 complex, that the bound inhibitor is present as an anion and that the aromatic ring of the inhibitor undergoes rapid rotation in the complex in spite of