A ternary complex of carbonic anhydrase: X-ray crystallographic structure of the adduct of human carbonic anhydrase II with the activator phenylalanine and the inhibitor azide
โ Scribed by Fabrizio Briganti; Valeria Iaconi; Stefano Mangani; Pierluigi Orioli; Andrea Scozzafava; Guido Vernaglione; Claudiu T. Supuran
- Book ID
- 108331665
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 746 KB
- Volume
- 275-276
- Category
- Article
- ISSN
- 0020-1693
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๐ SIMILAR VOLUMES
The binding of four inhibitors--mercuric ion, 3-acetoxymercuri-4-aminobenzenesulfonamide (AMS), acetazolamide (Diamox), and thiocyanate ion--to human carbonic anhydrase II (HCA II) has been studied with X-ray crystallography. The binding of mercury to HCA II at pH 7.0 has been investigated at 3.1 A
We investigated the inhibitory activity of several 1,3,4-thiadiazole-sulfonamides against all catalytically active CA (EC 4.2.1.1), CA I-XV. The tail derivatizing the 5-position in the 1,3,4-thiadiazole-2-sulfonamide scaffold was observed to be critical as an inhibitory determinant of these compound