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Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase

โœ Scribed by Francesco Abbate; Jean-Yves Winum; Barry V.L. Potter; Angela Casini; Jean-Louis Montero; Andrea Scozzafava; Claudiu T. Supuran


Book ID
108073120
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
258 KB
Volume
14
Category
Article
ISSN
0960-894X

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Carbonic anhydrase inhibitors. The X-ray
โœ Balendu Sankara Avvaru; Jason M. Wagner; Alfonso Maresca; Andrea Scozzafava; Art ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 916 KB

We investigated the inhibitory activity of several 1,3,4-thiadiazole-sulfonamides against all catalytically active CA (EC 4.2.1.1), CA I-XV. The tail derivatizing the 5-position in the 1,3,4-thiadiazole-2-sulfonamide scaffold was observed to be critical as an inhibitory determinant of these compound