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Fluorine NMR studies of the human carbonic anhydrase–3,5-difluorobenzenesulfonamide complex

✍ Scribed by D. L. Veenstra; J. T. Gerig

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 274 KB
Volume: 36
Category: Article
ISSN: 0749-1581
DOI: 10.1002/(sici)1097-458x(199806)36:13<s169::aid-omr320>3.0.co;2-#

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✦ Synopsis

Fluorine and nitrogen-15 NMR experiments are described which show that 3,5-diÑuorobenzenesulfonamide binds to human carbonic anhydrase I in a 1 : 1 complex, that the bound inhibitor is present as an anion and that the aromatic ring of the inhibitor undergoes rapid rotation in the complex in spite of likely interactions with the aromatic ring of Phe-91 which are strong enough to give an appreciable 19FM1HN NOE. A previously predicted enhancement of binding by Ñuorination of the inhibitor was conÐrmed.

1998 John Wiley & ( Sons, Ltd.

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