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NK4 Gene Therapy Inhibits HGF/Met-Induced Growth of Human Cholangiocarcinoma Cells

✍ Scribed by Ge, Xianxiu; Wang, Youli; Wang, Yun; Li, Quanpeng; Yu, Hong; Miao, Lin

Book ID
120392383
Publisher
Springer US
Year
2013
Tongue
English
Weight
636 KB
Volume
58
Category
Article
ISSN
0163-2116

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✍ Yoshinori Suzuki; Katsuya Sakai; Junko Ueki; Qing Xu; Takahiro Nakamura; Hideaki πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 French βš– 707 KB

## Abstract NK4 exhibits two distinct biological actions: antagonistic inhibition of hepatocyte growth factor (HGF) through binding to the Met/HGF receptor, and antiangiogenic action through binding to perlecan. Here, the anti‐tumor effect of NK4 on malignant pleural mesothelioma was investigated.