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Concomitant expression of hepatocyte growth factor (HGF), HGF activator and c-met genes in human glioma cells in vitro

✍ Scribed by Takuzou Moriyama; Hiroaki Kataoka; Hirohito Tsubouchi; Masashi Koono


Book ID
115931287
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
508 KB
Volume
372
Category
Article
ISSN
0014-5793

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Expression of c-Met, the receptor for hepatocyte growth factor (HGF). and the biological roles of HGF were examined in cultured human glioma cells. All of the 5 glioma cell lines examined expressed c-Met protein as well as the c-met gene. Expression of the c-met gene was also confirmed in a glioblas

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## Abstract Hepatocyte growth factor/scatter factor (HGF/SF) is a multifunctional growth factor that is involved in invasive growth of tumor cells __via__ its receptor MET, a protein product of __c‐met__ proto‐oncogene. HGF activator (HGFA) is a serine proteinase responsible for the activation of p