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Inhibition of HGF/SF-induced breast cancer cell motility and invasion by the HGF/SF variant, NK4

✍ Scribed by Stephen Hiscox; Christian Parr; Toshikazu Nakamura; Kunio Matsumoto; Robert E. Mansel; Wen G. Jiang


Book ID
110234501
Publisher
Springer US
Year
2000
Tongue
English
Weight
131 KB
Volume
59
Category
Article
ISSN
0167-6806

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Nk4, a new HGF/SF variant, is an antagon
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Hepatocyte Growth Factor/Scatter Factor (HGF/SF) is a heterodimeric molecule that plays a key role in the regulation of migration, invasion and angiogenesis in cancer, via activation of its receptor, c-met. HGF/SF is composed of an alpha-chain, containing the N-terminal hairpin domain and 4 kringle

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## Abstract Hepatocyte growth factor/scatter factor (HGF/SF) is a multi‐function cytokine that has been shown to regulate the expression of cell adhesion molecules in human endothelial cells. It is also a key cytokine in the development and progression of cancer, particularly during metastasis. NK4