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Nitric oxide synthase: Irreversible inhibition by L-NG-Nitroarginine in brain in vitro and in vivo

✍ Scribed by Mary A. Dwyer; David S. Bredt; Solomon H. Snyder


Book ID
115763854
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
389 KB
Volume
176
Category
Article
ISSN
0006-291X

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Inhibition of Bovine Brain Nitric-Oxide
✍ J.G. Robertson; M.S. Bernatowicz; A.M. Dhalla; B.B. Muhoberac; J. Yanchunas; G.R πŸ“‚ Article πŸ“… 1995 πŸ› Elsevier Science 🌐 English βš– 426 KB

Three derivatives of the mechanism-based inhibitor \(N^{\mathrm{G}}\)-allyl-L-arginine, designed to eliminate the effect of charge on the \(\alpha\)-functional groups, were synthesized and tested as inhibitors of purified bovine brain nitric oxide synthase. The inhibitory properties of \(N^{\mathrm{