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Differential changes in rat brain nitric oxide synthase in vivo and in vitro by methylmercury

✍ Scribed by Masaru Shinyashiki; Yoshito Kumagai; Hiromi Nakajima; Jun Nagafune; Shino Homma-Takeda; Masaru Sagai; Nobuhiro Shimojo


Book ID
114003963
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
308 KB
Volume
798
Category
Article
ISSN
0006-8993

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A free radical, nitric oxide (NO), besides being a messenger molecule in the brain, becomes a neurotoxin if overproduced. We recently reported that methylmercury (MeHg) induces neuronal NO synthase (nNOS) in Purkinje cells. In the present study, we examined the distribution and the mechanism of nNOS