Differential changes in rat brain nitric oxide synthase in vivo and in vitro by methylmercury
β Scribed by Masaru Shinyashiki; Yoshito Kumagai; Hiromi Nakajima; Jun Nagafune; Shino Homma-Takeda; Masaru Sagai; Nobuhiro Shimojo
- Book ID
- 114003963
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 308 KB
- Volume
- 798
- Category
- Article
- ISSN
- 0006-8993
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A free radical, nitric oxide (NO), besides being a messenger molecule in the brain, becomes a neurotoxin if overproduced. We recently reported that methylmercury (MeHg) induces neuronal NO synthase (nNOS) in Purkinje cells. In the present study, we examined the distribution and the mechanism of nNOS