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Nigral Cell Loss Produced by Infusion of Isoquinoline Derivatives Structurally Related to 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine

✍ Scribed by Kevin St.P. McNaught; Ulrike Thull; Pierre-Alain Carrupt; Cosimo Altomare; Saverio Cellamare; Angelo Carotti; Bernard Testa; Peter Jenner; C.David Marsden


Book ID
118769248
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
397 KB
Volume
5
Category
Article
ISSN
1055-8330

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## Abstract We assessed the presence of degenerating neurons in the substantia nigra pars compacta (SNpc) and ventral tegmental area (VTA) of parkinsonian monkeys. For this purpose, we used two histological markers of cellular death, Fluoro Jade B (FJB) staining and terminal deoxynucleotidyl transf