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Nicotine-11C: Synthesis and distribution kinetics in animals

✍ Scribed by Mariannick Mazière; Dominique Comar; Christian Marazano; Gérard Berger

Book ID
104682994
Publisher
Springer
Year
1976
Tongue
English
Weight
359 KB
Volume
1
Category
Article
ISSN
0340-6997

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✦ Synopsis

In order to study "in vivo" the distribution kinetics of (-)-nicotine in animals, this molecule was labeled with carbon-11. Two synthesis methods are described. Immediately after intravenous administration of (-)-nicotine-methyl-11C in rabbits the gamma-camera shows a strong radioactivity build-up in the brain and kidneys. The biological interest of this carbon-11 labeled molecule is discussed.

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