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Nickel-complex-catalyzed addition of methanol to esters of α,β-unsaturated acids

✍ Scribed by U. M. Dzhemilev; R. N. Fakhretdinov; G. A. Tolstikov


Book ID
112437548
Publisher
Springer
Year
1977
Tongue
English
Weight
309 KB
Volume
26
Category
Article
ISSN
1573-9171

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We have found that in the presence of fluoride ion, nitrotoluenes of type 1 undergo Michael addition to activated a, p-unsaturated esters of type 2 in good to excellent yield (Scheme 1). The generality and limitation of this reaction and its application to the chiral synthesis of benzazepine 4 are d