We have found that in the presence of fluoride ion, nitrotoluenes of type 1 undergo Michael addition to activated a, p-unsaturated esters of type 2 in good to excellent yield (Scheme 1). The generality and limitation of this reaction and its application to the chiral synthesis of benzazepine 4 are d
✦ LIBER ✦
Rhodium-catalyzed michael additions of activated nitriles to α,β - unsaturated esters
✍ Scribed by Stefano Paganelli; Alberto Sehionato; Carlo Botteghi
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 238 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
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a-Lithiated phosphonates added to a&unsaturated t-butyl esters in 1,Gmanner giving anti-3,4-disubstituted-4-phosphorylbutanoates in high yields. /~~%~ylam%omethyl)phosphonates were prepared from dialkyl phosphite, dibenzylamine, and formaldehyde: See; R. Tyka, Tetrahedron Lett., 1970, 677.