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NF2 Mutations in Secretory and Other Rare Variants of Meningiomas

✍ Scribed by Christian Hartmann; Jennifer Sieberns; Claire Gehlhaar; Matthias Simon; Werner Paulus; Andreas von Deimling

Book ID
111404413
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
203 KB
Volume
16
Category
Article
ISSN
1015-6305

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## Abstract The __NF2__ gene is a putative tumor‐suppressor gene that, when it is altered in the germline, causes neurofibromatosis type 2, a tumor‐susceptibility disease that mainly predisposes to schwannomas and meningiomas. The recent isolation of the __NF2__ gene on chromosome 22 allows the ide

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## Abstract Deletions of chromosome 22 have been identified in 3 types of childhood primary brain tumor: meningiomas, rhabdoid or atypical teratoid tumors (ATT) and ependymomas. This implicates the involvement of tumor suppressor genes on chromosome 22 in the genesis of these rare tumors. One such