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NF2 gene mutations and allelic status of 1p, 14q and 22q in sporadic meningiomas

✍ Scribed by Leone, Paola E; Bello, M Josefa; Campos, Jose M de; Vaquero, Jesus; Sarasa, Jose L; Pestaña, Angel; Rey, Juan A

Book ID: 110061977
Publisher: Nature Publishing Group
Year: 1999
Tongue: English
Weight: 215 KB
Volume: 18
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1202531

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## Abstract The role of the __NF2__ gene in the development of meningiomas has recently been documented; inactivating mutations plus allelic loss at 22q, the site of this gene (at 22q12), have been identified in both sporadic and neurofibromatosis type 2–associated tumors. Although epigenetic inact