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Allelic Loss of 14q and 22q,NF2Mutation, and Genetic Instability Occur Independently of c-kitMutation in Gastrointestinal Stromal Tumor

✍ Scribed by Fukasawa, Tomoki ;Chong, Ja-Mun ;Sakurai, Shinji ;Koshiishi, Naoki ;Ikeno, Rie ;Tanaka, Akira ;Matsumoto, Yoshiro ;Hayashi, Yukiko ;Koike, Morio ;Fukayama, Masashi

Book ID: 108581864
Publisher: Wiley (Blackwell Publishing)
Year: 2000
Tongue: English
Weight: 112 KB
Volume: 91
Category: Article
ISSN: 0910-5050
DOI: 10.1111/j.1349-7006.2000.tb00910.x

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We previously reported NF2 mutations in malignant mesothelioma (MM) cell lines and corresponding primary tumors. We have now generated polyclonal antibodies that specifically recognize the C-terminus of the NF2 protein. Western blot analysis was performed on 25 MM cell lines, 14 of which showed no N