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Loss of chromosome 22 and absence of NF2 gene mutation in a case of multiple meningiomas

✍ Scribed by Jesus Lomas; M.Josefa Bello; M.Eva Alonso; Pilar Gonzalez-Gomez; Dolores Arjona; M.Elena Kusak; Jose M. De Campos; Jose L. Sarasa; Juan A. Rey


Book ID
117818729
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
119 KB
Volume
33
Category
Article
ISSN
1532-8392

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## Abstract The __NF2__ gene is a putative tumor‐suppressor gene that, when it is altered in the germline, causes neurofibromatosis type 2, a tumor‐susceptibility disease that mainly predisposes to schwannomas and meningiomas. The recent isolation of the __NF2__ gene on chromosome 22 allows the ide

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## Abstract Cytogenetic studies of eight meningiomas in young children or adolescents were performed. Two tumors exhibited normal karyotypes. Two tumors from patients with bilateral acoustic neurofibromatosis demonstrated monosomy 22 as the only abnormality. Four patients had more complicated karyo