✦ LIBER ✦

Abnormalities of chromosome 22 in pediatric meningiomas

✍ Scribed by Dr. Jaclyn A. Biegelm; Beverly S. Emanuel; Annette H. Parmiter; Leslie N. Sutton; Lucy B. Rorke

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 542 KB
Volume: 9
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870090202

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Cytogenetic studies of eight meningiomas in young children or adolescents were performed. Two tumors exhibited normal karyotypes. Two tumors from patients with bilateral acoustic neurofibromatosis demonstrated monosomy 22 as the only abnormality. Four patients had more complicated karyotypes in which one or both of the chromosomes 22 were missing or structurally altered. The most common secondary changes in these four tumors involved monosomy or structural abnormalities of Chromosome 6. These findings confirm that the primary cytogenetic changes in meningioma are similar in children and adults. Molecular analyses of pediatric meningiomas with deletions or translocations of chromosome 22 will be useful for identifying the role of chromosome 22 tumor suppressor genes in this disease. Genes Chrorn Cancer 9:81‐87 (1994). © 1994 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Chromosome abnormalities in multiple men

Chromosome abnormalities in multiple meningiomas of a child

✍ Dr. Bernd Wullich; Lothar Mayfrank; Karl Schwechheimer; Jürgen Finke; Werner Sch 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 228 KB

We report the cytogenetic findings in two meningiomas from a child presenting with multiple meningiomas. In contrast to the chromosomal profile of adult meningiomas, both tumors studied revealed excess of chromosomes in addition to monosomy 22. This difference is remarkable considering several repor

Deletions on chromosome 22 in sporadic m

Deletions on chromosome 22 in sporadic meningioma

✍ Martin H. Ruttledge; Ya-Gang Xie; Fei-Yu Han; Myriam Peyrard; V. Peter Collins; 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 733 KB

Meningiomas are the second most common group of primary central nervous system tumors in humans. Cytogenetic and molecular studies imply that genes involved in the primary development of meningioma reside on chromosome 22. The recently characterized neurofibromatosis type 2 gene (NFZ) has been shown

Chromosome 22 monosomy in a radiation-in

Chromosome 22 monosomy in a radiation-induced meningioma

✍ C. A. Pagni; S. Canavero; F. Fiocchi; G. Ponzio 📂 Article 📅 1993 🏛 Springer Milan 🌐 English ⚖ 155 KB

Multiple meningiomas in a patient with c

Multiple meningiomas in a patient with constitutional ring chromosome 22

✍ Petrella, Rena ;Levine, Seymour ;Wilmot, Patrick L. ;Ashar, Kunjlata D. ;Casamas 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 360 KB 👁 2 views

We report on a patient with multiple congenital anomalies and ring chromosome 22 who died at age 16 years of bronchopneumonia. Autopsy documented multiple psammomatous meningiomas of the spinal dura and tentorium. n m o r tissue for cytogenetic analysis was not available. Although abnormalities of c

Ciliary ultrastructural abnormalities in

Ciliary ultrastructural abnormalities inMycoplasma pneumoniaepneumonia in 22 pediatric patients

✍ Hui Liang; Wujun Jiang; Qing Han; Feng Liu; Deyu Zhao 📂 Article 📅 2011 🏛 Springer 🌐 English ⚖ 221 KB

Deletion mapping of the long arm of chro

Deletion mapping of the long arm of chromosome 22 in human meningiomas

✍ Kenzo Akagi; Hiroki Kurahashi; Norio Arita; Toru Hayakawa; Morito Monden; Takesa 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 678 KB

Cytogenetic and molecular genetic analyses have shown that a tumor-suppressor gene for human meningioma is located on the long arm of chromosome 22. Recently, somatic mutations of the NF2 gene have been identified in sporadic meningiomas. However, tumorigenesis of certain cases of meningioma cannot